Iimveliso
2,4-Diamino-6-hydroxypyrimidine 2,6-Diamino-4-Hydroxyprimidine
Izithethantonye:4 (1H) -Pyrimidinone,2,6-diamino- (8CI,9CI);2,4-Diamino-6-hydroxypyrimidine;2,4-Diamino-6-pyrimidinone;2,6-Diamino-3,4 -dihydropyrimidin-4-enye;2,6-Diamino-4 (1H) -pyrimidinone;2,6-Diamino-4 (3H) -pyrimidinone;2,6-Diamino-4-hydroxypyrimidine;2,6-Diamino-4 -pyrimidinol;2,6-Diaminopyrimidin-4-enye;2,6-Diaminopyrimidine-4 (3H)-enye;6-Aminoisocytosine;6-Hydroxy-2,4-pyrimidinediamine;NSC 44914;NSC 680818;NSC9302;
Ipropati yeMichiza ye-2,4-Diamino-6-hydroxypyrimidine
● Imbonakalo/uMbala: okuqinileyo okumhlophe
● Uxinzelelo lomphunga: 0.00232mmHg kwi-25 ° C
● Indawo ekunyibilika kuyo: 285-286 °C (dec.)(lit.)
● Refractive Index:1.7990 (uqikelelo)
● Indawo yokuBilisa: 288.5 °C kwi-760 mmHg
● I-PKA: 10.61±0.50(Iqikelelweyo)
● Indawo yokudanyaza:128.3 °C
● PSA:98.05000
● Ubuninzi: 1.84 g/cm3
● I-LogP: 0.50900
● Ubushushu boGcino: Nciphisa kwi +4°C
● Bunovelwano.:Inobuthathaka bokukhanya
● Ukunyibilika.:DMSO (Kancinci), iMethanol (Kancinci)
Ubunyulu/Umgangatho
I-99% *idatha evela kubaboneleli abakrwada
I-2,4-Diamino-6-hydroxypyrimidine * idatha evela kubanikezeli be-reagent
Ulwazi oluKhuselekileyo
● IiPictogram:
Xi
● Iikhowudi zeeNgozi:Xi
● Iingxelo: 36/37/38
● Iingxelo zoKhuseleko: 22-24/25-36-26
Iluncedo
● Inkcazo: I-2,4-Diamino-6-hydroxypyrimidine (DAHP) yinto ekhethiweyo, inhibitor ethile ye-GTP cyclohydrolase I, inqanaba lokukhawulela inqanaba le-de novo pterin synthesis.Kwiiseli ze-HUVEC, i-IC50 ye-inhibition ye-BH4 biosynthesis imalunga ne-0.3 mM.I-DAHP ingasetyenziselwa ukubhloka ngokufanelekileyo HAYI imveliso kwiintlobo ezininzi zeeseli.
● Ukusetyenziswa: I-2,4-Diamino-6-hydroxypyrimidine (DAHP) yinto ekhethiweyo, inhibitor ethile ye-GTP cyclohydrolase I, inqanaba lokukhawulela inqanaba le-de novo pterin synthesis.Kwiiseli ze-HUVEC, i-IC50 ye-inhibition ye-BH4 biosynthesis imalunga ne-0.3 mM.I-DAHP ingasetyenziselwa ukuvala ngokufanelekileyo imveliso ye-NO kwiintlobo ezininzi zeeseli.[Cayman Chemical] Ima ekuqaleni kwe-enzyme-catalyzed cascade eqala ngale carbohydrates-carbon esixhenxe kwaye iphele nge-amino acids enuka kamnandi phenylalanine, tyrosine, kunye ne-tryptophan. I-2,4-Diamino-6-hydroxypyrimidine (i-cas # 56-06-4) i-compound iluncedo kwi-organic synthesis.
I-2,4-Diamino-6-hydroxypyrimidine i-chemical compound kunye ne-molecular formula C4H6N4O.Isetyenziswa ngokuqhelekileyo njengendawo ephakathi kwi-synthesis yamacandelo ahlukeneyo, kubandakanywa iziyobisi zamachiza kunye ne-dyes.I-compound inesakhiwo se-pyrimidine ring equkethe amaqela amabini e-amino (NH2) kunye neqela elinye le-hydroxyl (OH) elifakwe kwii-athomu zekhabhoni ezahlukeneyo.Esi sakhiwo senza ukuba kube yinto eguquguqukayo yokwakha i-synthesis ye-molecule eyinkimbinkimbi.Inezicelo ezininzi kumashishini amayeza, ngokukodwa kwi-synthesis yamachiza e-anti-cancer kunye ne-antibiotics.Kuko konke, i-2,4-Diamino-6-hydroxypyrimidine iyikhompawundi ebalulekileyo efumana uncedo kwizicelo ezahlukeneyo zeekhemikhali kunye nezamayeza.
