I-2,4-Diamino-6-hydroxypyrimidine

Inkcazelo emfutshane:

Igama lemveliso:I-2,4-Diamino-6-hydroxypyrimidine

Izithethantonye:I-TIMTEC-BB SBB004252;2,4-DIAMINOPYRIMIDIN-6-OL;2,4-DIAMINO-6-HYDROXYPYRIMIDINE;2,4-DIAMINO-6-PYRIMIDINOL;2,4-DIAMINO-6(1H)-PYRIMIDINONE;2,2; I-6-DIAMINO-4-PYRIMIDINOL;2,6-DIAMINO-4-PYRIMIDINONE;2,6-DIAMINOPYRIMIDIN-4-OL

I-CAS:56-06-4

MF:I-C4H6N4O

MW:126.12

EINECS:200-254-4

Iindidi zeeMveliso:I-Pyrimidines;Iibhloko zokwakha;PYRIMIDINE;C4 ukuya kwiC5;I-Chemical Synthesis;i-Heterocyclic Building Blocks;APIs & Intermediate;Pyridines, Pyrimidines, Purines and Pteredines;Chemical Amines;13C & 2H Sugars;Amines;Iziseko &Ii-Heterocyclic Reagents; & Neziphuma;bc0001

Ifayile yeMol:56-06-4.mol

Thumela i-imeyile kuthi

Iinkcukacha zeMveliso

Iithegi zeMveliso

Iipropati zeMichiza yeHydroxypyrimidine

Indawo yokunyibilika	285-286 °C (dec.) (lit.)
Indawo yokubilisa	234.22°C (uqikelelo olurhabaxa)
ukuxinana	1.3659 (uqikelelo olurhabaxa)
isalathiso se-refractive	1.7990 (uqikelelo)
ixesha lokugcina.	Gcina kwindawo emnyama, umoya ongena ngaphakathi, ubushushu begumbi
ukunyibilika	I-DMSO (Kancinci), iMethanol (Kancinci)
pka	10.61±0.50(Kuqikelelwe)
ifomu	Umgubo ococekileyo weCrystalline
umbala	Emhlophe ukuya kwikhilimu
Inovakalelo	Ukukhanya okunovelwano
Merck	14,2981
I-BRN	125006
InChIKey	SWELIMKTDYHAOY-UHFFFAOYSA-N
CAS Database Reference	56-06-4(I-CAS DataBase Reference)
NIST Chemistry Reference	4(1H)-pyrimidinone, 2,6-diamino-(56-06-4)
EPA Substance Registry System	2,6-Diamino-4(1H)-pyrimidinone (56-06-4)

Inkcazo yeMveliso yeHydroxypyrimidine

I-2,4-Diamino-6-hydroxypyrimidine i-chemical compound kunye ne-molecular formula C4H6N4O.Yikhompawundi ephilayo yentsapho yepyrimidine.I-compound inesakhiwo sendandatho ye-pyrimidine, amaqela amabini e-amino (NH2) axhunyiwe kwi-2-position kunye ne-4-position, kunye neqela le-hydroxyl (OH) lixhunyiwe kwi-6-position.Ulwakhiwo lweekhemikhali lunokubonakaliswa njenge: Ammonia ||H--C--C--C--N--C--C--NH2 || oh 2,4-Diamino-6-hydroxypyrimidine inezicelo ezahlukeneyo kwishishini lamachiza.Yinto ebalulekileyo ephakathi kwi-synthesis yamachiza amaninzi, kubandakanywa ne-antiviral kunye ne-antitumor drug.Ikwasetyenziselwa ukuvelisa ii-nucleotide analogs ezininzi ezisetyenziswa kuphando lwamayeza.

Ukongeza kwizicelo zamachiza, i-2,4-diamino-6-hydroxypyrimidine iphinda isetyenziswe njengesithako kwi-agrochemicals.Sisithako esiphambili ekudityanisweni kwabalawuli bokukhula kwezityalo kunye nemichiza yokungunda.Kubaluleke kakhulu ukulandela iprotocol efanelekileyo yokhuseleko xa usebenzisa i-2,4-diamino-6-hydroxypyrimidine.Ekubeni ichazwa njengento ecaphukisa imichiza, ifanele iphathwe ngenkathalo kwaye izixhobo ezifanelekileyo zokuzikhusela kufuneka zinxitywe ukuphepha ukunxibelelana ngokuthe ngqo.

Isishwankathelo, i-2,4-diamino-6-hydroxypyrimidine i-organic compound kunye nezicelo kwiinkalo zamachiza kunye nezolimo.Ubume bayo beekhemikhali buyenza ibe luncedo njengendawo ephakathi kwi-syntheutical yamayeza kunye nabalawuli bokukhula kwezityalo.

Ulwazi ngoKhuseleko

Iikhowudi zeNgozi	Xi
Iingxelo zoMngcipheko	36/37/38
Iingxelo zoKhuseleko	22-24/25-36-26
WGK eJamani	3
Inqaku Lengozi	Iyacaphukisa
I-TSCA	Ewe
Ikhowudi ye-HS	29335995

Ukusetyenziswa kweHydroxypyrimidine kunye ne-Synthesis

Inkcazo	I-2,4-Diamino-6-hydroxypyrimidine (i-DAHP) yinto ekhethiweyo, inhibitor ethile ye-GTP cyclohydrolase I, inqanaba lokunciphisa izinga le-de novo pterin synthesis.Kwiiseli zeHUVEC, i-IC₅₀ngenxa yokuthintela i-BH₄i-biosynthesis imalunga ne-0.3 mM.I-DAHP ingasetyenziselwa ukubhloka ngokufanelekileyo HAYI imveliso kwiintlobo ezininzi zeeseli.
Iipropati zeMichiza	Okumhlophe Okuqinileyo
Usebenzisa	I-2,4-Diamino-6-hydroxypyrimidine (i-DAHP) yinto ekhethiweyo, inhibitor ethile ye-GTP cyclohydrolase I, inqanaba lokunciphisa izinga le-de novo pterin synthesis.Kwiiseli ze-HUVEC, i-IC50 ye-inhibition ye-BH4 biosynthesis imalunga ne-0.3 mM.I-DAHP ingasetyenziselwa ukubhloka ngokufanelekileyo i-NO imveliso kwiintlobo ezininzi zeeseli.[Cayman Chemical]
Usebenzisa	Ima ekuqaleni kwe-enzyme-catalyzed cascade eqala ngale carbohydrate esixhenxe-carbon kwaye iphele ngeamino acids enuka kamnandi phenylalanine, tyrosine, kunye ne-tryptophan.
Usebenzisa	I-2,4-Diamino-6-hydroxypyrimidine (i-cas # 56-06-4) i-compound iluncedo kwi-organic synthesis.
Iindlela zokucoca	Iphinda ikristale ukusuka kwi-H2O.[Beilstein 25 III/IV 3642.]