Iimveliso
I-6-Methyluracil 2,4-Dihydroxy-6-methylpyrimidine
Iimpawu ezifanayo: i-6-methyluracil; i-6-methyluracil, i-14C-ibhalwe; i-AWD 23-15; i-AWD-23-15; i-methacil; i-methyluracil; i-pseudothymine
Ipropati yeMichiza ye-6-Methyluracil
● Inkangeleko/uMbala:mhlophe ukuya kumhlophe-ngaphandle kwekristale okuqinileyo okuqinileyo
● Uxinzelelo lomphunga: 1.16E-07mmHg kwi-25 ° C
● Indawo ekunyibilika kuyo:318 °C (dec.)(lit.)
● I-Refractive Index: 1.489
● Indawo yokuBilisa: 420.4 °C kwi-760 mmHg
● PKA:pK1:9.52 (25°C)
● Indawo eDanyazayo:208 °C
● PSA: 65.72000
● Ubuninzi: 1.226 g/cm3
● I-LogP:-0.62840
● Ubushushu bokugcina: umoya ongasebenziyo, ubushushu begumbi
● Ukunyibilika.:DMSO (Kancinci), iMethanol (Kancinci, ishushu, iSonicated)
● Ukunyibilika kwamanzi.:7 g/L (22 ºC)
● XLogP3:-0.8
● Ubalo lwe-Hydrogen Bond:2
● Ubalo lwe-Hydrogen Bond:2
● Ubalo lweBond eJikelekayo:0
● Ubunzima obuchanekileyo: 126.042927438
● Ukubala kweAtom eNzima:9
● Ukuntsonkotha:195
Ubunyulu/Umgangatho
I-99% *idatha evela kubaboneleli abakrwada
I-6-Methyluracil *idatha evela kubanikezeli be-reagent
Ulwazi oluKhuselekileyo
● IiPictogram:
Xn
● Iikhowudi zeeNgozi:Xn
● Iingxelo: 62-63
● Iingxelo zoKhuseleko: 36/37/39-45-36/37
Iluncedo
● Uncumo lweCanonical: CC1=CC(=O)NC(=O)N1
● Ukusetyenziswa: I-6-Methyluracil (i-cas # 626-48-2) i-compound iluncedo kwi-organic synthesis.6-Methyluracil, eyaziwa ngokuba yi-thymine okanye i-5-methyluracil, i-organic compound kunye ne-chemical formula C5H6N2O2.I-derivative ye-pyrimidine kunye necandelo le-nucleic acids.I-Thymine, kunye ne-adenine, i-cytosine, kunye ne-guanine, yenye yee-nucleobases ezine ezifumaneka kwi-DNA.I-Thymine idlala indima ebalulekileyo kwi-DNA ngokudibanisa ne-adenine ngokusebenzisa i-hydrogen bonding, isenza esinye sezibini ezisisiseko ezenza i-double helix structure.Ngokukodwa, i-thymine yenza iibhondi ezimbini ze-hydrogen kunye ne-adenine kwi-DNA.Kwi-RNA, i-uracil ithatha indawo ye-thymine kwaye yenza izibini ezisisiseko kunye ne-adenine.I-Thymine inoxanduva lokuthwala ulwazi lwezofuzo ngaphakathi kwe-molecule ye-DNA.Isebenza njengeplani yokwenziwa kweeprotheni kwaye idlala indima ephambili ekuhanjisweni kweempawu zofuzo ukusuka kwesinye isizukulwana ukuya kwesinye.Ngaphandle kwendima yayo kwi-DNA kunye ne-RNA, i-thymine nayo isebenza njengento ekujoliswe kuyo ebalulekileyo kumachiza e-anticancer.Ezinye ii-chemotherapeutic agents zijolise kwi-enzymes enoxanduva lokudibanisa i-thymine, ngaloo ndlela ivimbela ukukhula kweeseli zomhlaza.Xa uphatha i-thymine, kubalulekile ukulandela iiprothokholi ezifanelekileyo zokhuseleko lwebhubhoratri, kubandakanywa ukugqoka izixhobo ezifanelekileyo zokukhusela nokusebenza kwindawo enomoya.Ukongezelela, i-thymine kufuneka igcinwe kwindawo eyomileyo nepholileyo ukukhusela ukuthotywa kunye nokugcina ukuzinza kwayo.
