Di-tert-butyl dicarbonate

Inkcazelo emfutshane:

Igama lemveliso:Di-tert-butyl dicarbonate

Izithethantonye:(BOC)2O;(BOC)2O FLUKA;BOC;BOC ANHYDRIDE;tert-butyldicarbonate;PYROCARBONIC ACID DI-TERT-BUTYL ESTER;RARECHEM TB OC 0001;Boc Anhydride, eqinileyo/emanzi

I-CAS:24424-99-5

MF:C10H18O5

MW:218.25

EINECS:246-240-1

Iindidi zeeMveliso:IziPhakathi zaMayeza;Ukuqalisa iMathiriyeli ekrwada & neziPhakathi;Izinto eziphuma kwiAmino Acid;Izinto eziphilayo;N-UKhuselo lweReagents;Biochemistry;Peptide Synthesis;UKhuseleko kunye neReagents zokuphuma (kwiSynthesis);Izinto eziKhuselayo (iPeptide Synthesis);IiRejenti zeOligosanic Checheride; Uchungechunge lwe-Boc-Amino acid;Iizinto eziziZinzo;DIBOC;1H-Inden-1-ol;bc0001;24424-99-5

Ifayile yeMol:24424-99-5.mol

Thumela i-imeyile kuthi

Iinkcukacha zeMveliso

Iithegi zeMveliso

Di-tert-butyl dicarbonate Chemical Properties

Indawo yokunyibilika	23 °C (lit.)
Indawo yokubilisa	56-57 °C/0.5 mmHg (lit.)
ukuxinana	0.95 g/mL ku-25 °C (lit.)
uxinzelelo lomphunga	3.85Pa ku-25℃
isalathiso se-refractive	n20/D 1.409(lit.)
Fp	99 °F
ixesha lokugcina.	2-8°C
ifomu	ICrystalline eNyibilikayo ePhantsi eSolid
umbala	Mhlophe
Ubunzima obuthile	0.950
Ukunyibilika kwamanzi	I-Miscible kunye ne-decalin, i-toluene, i-carbon tetrachloride, i-tetrahydrofuran, i-dioxane, i-alcohol, i-acetone, i-acetonitrile kunye ne-dimethylformamide.Ukungahambelani namanzi.
Inovakalelo	Ukungenwa kukufuma
I-BRN	1911173
InChIKey	DYHSDKLCOJIUFX-UHFFFAOYSA-N
LogP	1.87 ku-25℃
CAS Database Reference	24424-99-5(i-CAS DataBase Reference)
EPA Substance Registry System	Dicarbonic acid, bis(1,1-dimethylethyl) ester (24424-99-5)

Ulwazi ngoKhuseleko

Iikhowudi zeNgozi	T+,T,F,Xi,F+
Iingxelo zoMngcipheko	11-19-26-36/37/38-43-10-40
Iingxelo zoKhuseleko	16-26-28-36/37-45-7/9-37/39-24-36/37/39-33
I-RIDADR	UN 2929 6.1/PG 1
WGK eJamani	3
RTECS	HT0230000
F	4.4-10-21
Autoignition Temperature	460 °C
Inqaku Lengozi	Iyatsha / iyacaphukisa / inetyhefu kakhulu
I-TSCA	Ewe
I-HazardClass	6.1
Iqela lokupakisha	I
Ikhowudi ye-HS	29209010
Ubutyhefu	LD50 ngomlomo kuMvundla: > 5000 mg/kg LD50 dermal Rabbit > 2000 mg/kg

Ukusetyenziswa kweDi-tert-butyl dicarbonate kunye ne-Synthesis

Iipropati zeMichiza	I-Di-tert-butyl dicarbonate (i-BOC Anhydride, i-DiBOC) ayinambala ukuya kumhlophe ukuya kwiikristale ezityheli, ubunzima obuqinileyo okanye ulwelo olucacileyo.Iyanyibilika kubushushu begumbi (mp=23°C).Ayiboli ngoku okanye kumaqondo obushushu aphezulu kancinci.Umzekelo, ngokuqhelekileyo icocwa ngokuxutywa kwe-distillation phantsi koxinzelelo oluncitshisiweyo kumaqondo obushushu ukuya kuma-65 ° C.Kwiqondo lokushisa eliphezulu liya kubola kwi-isobutene, i-t-butyl alcohol kunye ne-carbon dioxide.
Usebenzisa	I-Di-tert-butyl dicarbonate (Boc2O) sisixhobo esisetyenziswa kakhulu ukwazisa amaqela akhuselayo kwi-peptide synthesis.Idlala indima ebalulekileyo ekulungiseleleni i-6-acetyl-1,2,3,4-tetrahydropyridine ngokuphendula nge-2-piperidone.Isebenza njengeqela elikhuselayo elisetyenziswa kwi-peptide synthesis yesigaba esiqinileyo.
Ukulungiselela	Ukulungiswa kweDi-tert-butyl dicarbonate ngolu hlobo lulandelayo: Kwisisombululo setyuwa yesodium ye-monoester yongezwa i-2g ye-N, i-N-dimethylformamide, i-1g ye-pyridine, i-1g ye-triethylamine, Ukupholisa ukuya kwi-5 ~ 0 ° C, i-60g ye-diphosgene yayicotha. i-dropwise eyongeziweyo ngaphakathi kwe-1.5h i-dropwise idibaniswe ngokupheleleyo, ifudunyezwe kwiqondo lokushisa (25 ° C), ifakwe kwi-2h, ukusabela kwavunyelwa ukuma emva kokucoca, ukuhlamba isisombululo se-organic.Yomiswe nge-anhydrous magnesium sulfate, i-solvent yachithwa kuxinzelelo lwe-atmospheric ukunika imveliso ekrwada engama-65 ~ 70g.Emva kokupholisa kunye ne-crystallization, i-57-60g ye-di-tert-butyl dicarbonate ifunyenwe kwisivuno se-60-63%.
Ingcaciso	I-ChEBI: I-Di-tert-butyl dicarbonate yi-acyclic carboxylic anhydride.Isebenza ngokunxulumene ne-dicarbonic acid.
Iimpendulo	Ukusabela kwee-anilines ezifakwe endaweni ye-Boc2O xa kukho isixa se-stoichiometric se-4-dimethylaminopyridine (DMAP) kwi-solvent engasebenziyo (i-acetonitrile, i-dichloromethane, i-ethyl acetate, i-tetrahydrofuran, i-toluene) kwiqondo lobushushu legumbi likhokelela kwi-aryl isocyanates phantse ngaphakathi kwe-quantitative quantitative 10. imiz. I-Di-tert-butyl dicarbonate kunye ne-4-(dimethylamino) pyridine iphinde yahlaziywa.Ukusabela kwabo nge-amines kunye notywala
Inkcazo ngokubanzi	Di-tert-butyl dicarbonate (Boc₂O) yi-reagent esetyenziselwa ukuqaliswa kweqela elikhuselayo le-Boc kwi-amine functionalities.Ikwasetyenziswa njengearhente yokukhupha amanzi emzimbeni kwezinye iintshukumo eziphilayo, ngakumbi nge-carboxylic acids, amaqela athile e-hydroxyl, okanye kunye ne-nitroalkanes yokuqala.
Ingozi	I-irritant enokubangela ukulimala kwamehlo kakhulu;Inokubangela ubuthathaka bolusu;Ityhefu kakhulu ngokuphefumla
Ukutsha kunye nokuSebenza	Ukutsha
Iindlela zokucoca	Nyibilikisa i-ester ngokufudumeza kwi ~ 35o, kwaye uyichithe kwindawo engenanto.Ukuba i-IR kunye ne-NMR (1810m 1765 cm-1, kwi-CCl4 1.50 singlet) icebisa ukungcola okuphezulu kakhulu, uze uhlambe ngomthamo olinganayo we-H2O equlethe i-citric acid ukwenza umaleko omanzi ube ne-asidi kancinane, uqokelele umaleko we-organic kwaye uyomise phezu kwe-anhydrous MgSO4 kwaye uyichithe kwivacuum.[uPope et al.Org Synth 57 45 1977, Keller et al.Org Synth 63 160 1985, Grehn et al.Angew Chem 97 519 1985.] ELINONYANYA.