Iimveliso
Di-tert-byyl dicarbonate; I-CAS: 24424-99-99
Izithethantonye: i-bis-butoxycarboll) i-oxide; i-BoC (2) o CPD; I-Boc2 tert-Byyl picarbonate; di-terter-bylldicarbonate
Ipropathi yamachiza e-di-te-terger-byyl dicarbonate
● Inkangeleko / umbala: White ukuya kwi-microcrystalline ye-microcrytalline
● Uxinzelelo lwe-vapor: 0.7mmhg nge-25 ° C
● Inqaku lokunyibilika: I-22-20 ° C
● Isalathiso seNgxelo yeNgxelo: 1.4090
● Inqaku lokubila: 235.8 ° C nge-760 mmhg
● Inqaku leFlash: i-103.7 ° C
● psa:I-61.83000
● Ukuxinana: 1.054 g / cm3
● I-LOGP: 2.87320
● Indawo yokugcina i-temp. -
● Ubuthathaka
● Ukuzola amanzi.
● I-XlogP3: 2.7
● I-Hydrogen Bop Count Count: 0
● Ubalo lwe-Hydrogen Bopptor: 5
● I-Count Chot Rot: 6
● Ubunzima obuthe ngqo: 218.11542367
● Ukubalwa kweatom enzima: 15
● Ukuntsonkotha: 218
Ulwazi olukhuselekileyo
● I-pictogram (s):
T, T +,
F, F +,
Xi
● Iikhowudi zeHazard: T + F, xi, F +
● Iingxelo: 11-19-26-366 / 37/8-4310-40
● Ingxelo zoKhuseleko: 16-26-28-366/75-7 / 9-37 / 37-362 / 39- 33 / 33- 33 / 33- 3333
Iluncedo
Iiklasi zekhemikhali:Ezinye iiklasi -> Esters, ezinye
I-Canonical iyancuma:I-CC (c) (c) oc (= o) oc (= o) oc (c) (c) c
IISEBE:I-Di-Terter-Byyl Dicarbonate (Boc2o) yi-regent esetyenziswe ngokubanzi yokwazisa amaqela okukhusela kwi-Synthesis Synthesis yePeptide. Idlala indima ebalulekileyo kumalungiselelo e-6-Acetyl-1,2,4-temrahydroprine ngokusabela nge-2-picridone. Isebenza njengeqela elikhuselayo elisetyenziswa kwiSigaba seSigaba seSigaba sePingade.
Intshayelelo Eneenkcukacha
Di-terter-byyl dicarbonateyindawo esetyenziswayo kwi-ornthesic synthesis. Ikwabizwa ngokuba yi-t-boc anhhydride okanye i-boc anhydride. Iqhelekile isetyenziselwa ukukhusela amaqela asebenza nge-amine ngexesha lokuphendula kwemichiza. I-Di-Tert-Byyl Dicarbonate iphinda iphinde iphinde isebenze kunye neemina ukwenza i-carbamate ye-carbamate, ukubonelela ngokhuseleko lwethutyana kwiqela le-Amine. Nje ukuba impendulo oyifunayo igqityiwe, iqela le-carbamate linokususwa ngokulula ngonyango nge-acid, ivelise ukusebenza kwe-amine ye-amine. Esi sisicwangciso esiliqili sokukhetha ngokukhetha amaqela athile asebenzayo kwiimolekyuli zezinto eziphilayo.
Isicelo
Ukongeza ekukhuseleni amaqela e-amine, i-di-te-te-te-bylbonate inezinye iinkqubo ezahlukeneyo kwiSynthesic Synthesi:
Ukukhuselwa kwamaqela e-hydroxyl:I-Di-Terter-Byyl Dicarbonate inokusabela ngamashala-kutywala ukwenza i-carcbonsates, ukukhusela iqela le-hydroxyl. Iqela le-carbonate linokuthi emva koko lisuswe ngokusebenzisa iimeko ezifanelekileyo, livumele ukukhetha okukhethiweyo kwamanye amaqela asebenzayo.
I-Carbonytion Reaction:I-Di-Tert-Byl Byl Dicarbonate inokusetyenziswa njengomthombo we-carbon monoxide kwi-carbongidetion. Inika ingxelo nge-nucleophiles ezinje ngemino, i-alcohols, kunye nee-tiols ukuba zenze iimveliso zekharbonylates.
Ukulungiswa kwe-acid chloride:Ukuphendula i-te-te-byllbonate dicarbonate ene-tionyl chloride okanye i-oxasl chloride ivelise i-hlorib ye-acid ehambelana ne-acid. I-acid chlorides isetyenziswa ngokudibeneyo irejista esetyenziswe kwiinguqu ezahlukeneyo zenguqu.
Isigaba seSigaba sePeptika:I-Di-Tert-Byyl Dicarbonate isetyenziswa rhoqo ekukhuseleni nasekusebenziseni amanyathelo kwi-Synthesis eqinileyo ye-Peptide. Isetyenziselwa ukukhusela i-amino acid ngexesha lolwandiso kunye nokususa amaqela okukhusela ukubonisa amaqela okukhusela ukubhengeza amaqela akwimisebenzi elandelayo yokudibanisa.
I-Polymerization Reaction:I-Di-Tert-Byyl Dicarbonate isebenza njengearhente yokudluliselwa kwe-chain kwi-polymerization yokuphendula. Inokusabela ngokukhula kwamakhonkco ePolymer, ukuphelisa ukukhula kwabo okanye ukuvelisa iindawo ezintsha zokusebenzela.
Le yimizekelo nje embalwa yezicelo ezininzi ze-di-byyl dicarbonate kwi-ornthesic synthesis. Ukusetyenziswa kwayo jikelele kunye nokuncipha kokusetyenziswa kwenza ukuba kubenze i-regent ebalulekileyo kwiinguqu ezahlukeneyo zemichiza.
