Iimveliso
Dicylohexylcarbodiimilbodiimil; I-CAS: 538-75-0-0-0
Izithethantonye: I-DCCD; dicylohexylCarbodiimide
Ipropathi yekhemikhali yeDiclohexylCylbodiimiimiimiimiimiimiimiimiimil
● Inkangeleko / umbala: Umbala oqinileyo
● Uxinzelelo lwe-vapor: 1.044-1.15pa nge-20-25 ℃
● Indawo yokunyibilika: 34-35 ° C (ikhanyisiwe.)
● Isalathiso sokwenza i-N20 / D 1.48
● Inqaku lokubila: I-277 ° C nge-760 mmhg
● Inqaku leFlash: 113.1 ° C
● psa:I-24.72000
● Ukuxinana: 1.06 g / cm3
● I-Logp: 3.82570
● Indawo yokugcina indawo.
● Ubuthathaka
● Solubi.: I-chloride: 0.1 g / ml, icacile, ayinabala
● Ukuzola amanzi
● I-XlogP3: 4.7
● I-Hydrogen Bop Count Count: 0
● Ubalo lwe-Hydrogen Bopptor: 2
● I-Count Count Count: 2
● Ubunzima obuthe ngqo: 206.172987710
● Ukubalwa kweatom enzima: 15
● Ukuntsonkotha: 201
● Ilebhile ye-DOT: Ityhefu
Ulwazi olukhuselekileyo
● I-pictogram (s):
T,
Xn
● Iikhowudi zengozi: t, Xn, +
● Iingxelo: 23/4 / 25-34- 35
● Ingxelo zoKhuseleko: 26-36 / 37/9-45-411
Iluncedo
Iiklasi zekhemikhali:I-Nitrogen Compows -> Ezinye ii-computer zeNitrogen
I-Canonical iyancuma:I-C1CCC (CC1) n = c = nc2cccc2
Inkcazelo:I-DicydoheXyl Carbodiimide isetyenziswa kwi-Camistry ye-camider njengendawo yokuhlangana kwakhona. Zombini ziyinto ecaphukisayo kunye nevangeli, kwaye zabangela ukunxibelelana ne-dermatitis kwi-phammacitists kunye noochwephesha.
IISEBE:Kwi-synthesis ye-peptides. Le mveliso isetyenziswa ikakhulu kwiAmikacacin, i-Glutathione Deghts, kunye neSyntdars, kunye neSynthedas ye-Acid Anhydride, i-Aldehyde, iKetonate; Xa isetyenziswa njengeHleyinti yeHesment, iphendula kwi-dicylohexylire yokuphendula yexesha elifutshane phantsi kobushushu obuqhelekileyo. Le mveliso inokusetyenziswa kwi-synthesi ye-peptide kunye ne-nucleic acid. Kulula ukusebenzisa le mveliso ukusabela nge-computer ye-carboxy yasimahla kunye ne-Amino-Group kwiPeplate. Le mveliso isetyenziswa ngokubanzi kwezonyango, impilo, yenza iimveliso zebhayoloji, kunye namanye amasimi owenziwayo. N, I-N'-DicylohexylCybylbodiimide yi-carbodiimide isetyenziselwa i-Amino Acino Amino Amid ngexesha lokuSynthesis. N, I-N'-DicylohexylboDIimide isetyenziswa njenge-arhente yokuphelelwa ngamathambo ukulungiselela, amaKenes, iiNqumathi kunye nokuzithemba kunye nokuzihlola kotywala wesibini. I-DicyloheXylCarboDIimide isetyenziswa njenge-arhente yokuphelelwa ngamandla kwiqondo lokushisa igumbi emva kwexesha elifutshane emva kokuphendula, emva kwemveliso yokuphendula yi-dicylohexylire. Imveliso incinci kakhulu i-solity esondla kwisinyithi-mthethweni, ukuze ukwahlulwa lula kwemveliso yokuphendula.
Intshayelelo Eneenkcukacha
Dicylohexylcarbodiimide (i-DCC) yindawo esetyenziswayo esetyenziswayo kwi-ornthesic synthesi. Sisiqili esimhlophe esinganyibilikisi emanzini kwaye sinyibilikisi kwiinyibilikisi zendalo ezinje nge-ethyl acetate naseDichloromethane.
I-DCC isetyenziswa njenge-arhente ye-Coupling kwi-Syntheside kunye nezinye izinto ezibandakanya ukumiswa kweebhondi ze-Amide. Ikhuthaza i-prosances ye-acidy ye-carxyylic kunye neminyibi Iphumeza oku ngokwenza iqela lebhokisi ye-carboxylic kunye nokwenza lula uhlaselo lwe-nucleophilic ye-amine kwi-carbonl ye-carbonl evulekileyo.
Ukongeza kwi-Synthesis Syntheside, i-DCC ikwasetyenziswa kwezinye izinto ezenziwa ngokomhlaba, ezinjengokuhambelana nokuphendula kwamandla. Inokuqeshwa ukwenza ii-esters ezivela kwi-carxboxylic acids kunye notywala, kunye nokuguqula i-carboxyylives (efana ne-acid chloride, i-Ecid Anneddrides, kunye ne-EARTSDDRRE, kunye ne-EARTSDDRDRE, kunye ne-EARTSDDRRE, kwaye isebenza ngamacala emidleleni.
I-DCC yaziwa ngokuba yimpumelelo enkulu ekukhuthazeni ukwakhiwa kwebhondi ye-amil kunye nokuhambelana kwamanani ahlukeneyo amaqela asebenzayo. Nangona kunjalo, ikwajongwa njengokufuma okunyanzelwa - ebuthathaka kwaye ingabonisa ngokulula ekuvezweni kwamanzi okanye kumswakama ophezulu. Ke ngoko, idla ngokuphathwa kwaye igcinwe phantsi kweemeko ezinamanzi.
Kubalulekile ukuthatha amanyathelo afanelekileyo okhuseleko xa usebenza ne-DCC, njengoko kunokuba kukucaphukisa ulusu, amehlo, kunye nenkqubo yokuphefumla. Ukungena komoya ngokufanelekileyo kunye nezixhobo zokhuselo lobuqu kufuneka zisetyenziswe ngexesha lokuphatha.
Isicelo
I-DicyloheXylCarboDIimide (i-DCC) ifumana izicelo ezahlukeneyo kwi-synthesic synthesis, ngakumbi kwicandelo le-calide chemistry. Nazi izicelo ezimbalwa ezithengiswayo ze-DCC:
I-Peptide Synthesis:I-DCC idla ngokusetyenziswa njenge-arhente yokudibanisa kwi-Peptheside kwi-Synthesis ye-Amino Acid kunye neFondi. Ikhuthaza ukuphendula kwi-Quences
Ukuphendula okukhulu:I-DCC ingasetyenziselwa ukuguqula i-carboxylic acids iphumelele e-Esters ngokusabela ngotywala. Phambi kwe-DCC, ibhokisi ye-carboxyylic acid ivuliwe, ivumela uhlaselo lwe-nucleophilic bulsty ukwenza i-ester. Le mpendulo iluncedo kwi-synthesis ye-Ests kwizicelo ezahlukeneyo.
Ukuphendula kwamandla:I-DCC inokuqhubela phambili umanyano lwee-carboxylic acids, i-acid chloride, i-acid adhydrides, kunye nee-esters. Ivumela ukuphendula phakathi kwe-carboxyylic acid ye-carboxylive kunye ne-amine ukuba yenze i-amilbond ye-amil. Esi sicelo sifumana isixhobo kwi-synthesis, esibalulekileyo kwiinkqubo ezahlukeneyo zebhayilicaralicas.
I-UUG Reance:I-DCC inokusetyenziswa kwi-UGI yokuphendula, i-mitestickoldeonetion yokuphendula ebandakanya ukuqinisekiswa kwe-Amine, i-staride, i-squbonyl equbezana, ne-acid. I-DCC inceda ekwenzeni iqela lebhokisi ye-acid, liyivumela ukuba liphendule nge-amine kwaye yenze i-amilbond bond.
Synthesis Synthesis:I-DCC ihlala isetyenziswa kumzi-mveliso wamachiza we-synthesis yamachiza amachiza kunye nezithako ezisebenzayo (APIS). Ukusetyenziswa kwayo kwi-Synthesides yePeptimade, imixholo, kunye nezinye iinguqu ezibalulekileyo kwenza ukuba kube yinto ebalulekileyo ekufumaneni iziyobisi kunye neenkqubo zophuhliso.
Kufanelekile ukuba i-DCC inezinye iinkqubo ezininzi kwi-synthesi ye-organic, kubandakanya ukumiselwa kwee-ureas, izakhiwo zemoto, kunye ne-hydrazas. Ukusetyenziswa kwendlela yayo kunye nokuhambelana namaqela ahlukeneyo emisebenzi kwenza isixhobo esibalulekileyo kwibhokisi yebhokisi yezixhobo ze-schenthecic.
