I-DL-4-chlorophenylglycine; I-CAS: 6212-33-5

Inkcazo emfutshane:

Igama leekhemikhali:I-2-Amino-2- (4-Chlophenyl) I-Acetic Acid
I-CAY NO .:6212-33-5
I-CASED ebonakalayo:I-7292-70-8
Ifomula yemolekyuli:C8h8clno2
Ubunzima bemolekyuli:185.61
Ikhowudi ye-HS;292249990
Inombolo yoLuntu yaseYurophu (EC):612-9444-6,674-625-8
III:Rm2jw43tga
I-IDSTOX I-ID ye-DSSSTOX:I-DTXSID40863712
Inombolo yeNingaji:J360.089k
I-ID ye-chembl:I-Chembl133182
Ifayile ye-MOL:I-6212-33-5.Mol

Iinkcukacha zemveliso

Iimpawu zeMveliso

Izithethantonye: 6212-33; I-Acid; 4-chlorophenylglycline; i-DL- (4-chlodi) i-vlycine; Acid, I-.lla. -Dl-PHG (4-Cl)-I-MTYLYN-COCYLN-COCBOAUAMAAMAAMAAMAAMAE; RM2JW43TGA; 2- (p-2- (i-DL-2- (i-DL-2- (CHLOPOPYL ); I-4-chloro-Dl-2-phenylglycine; i-DL-2- (p-chlophenid) i-Glycine, i-DLLLLLLLL); #; BCP25773; BBL022163; BDBM501305: I-Akos01305: 4-i-Amino-4-chlorobenzenzenzenezetic Acid; 7l-3044s; AB020994; AB15770; A-WO002237; I-ABLO-42337; I-DL-WOAP-4-CHLOPOCEMCECTT I-acid; Sy017756; Sy03415; Sy034129; (+); (I-TLC); I-Q-102258; F2147-0645; Z31746; (+/) -

Ipropathi yamachiza ye-DL-4-chlorophenylglycine

● Inkangeleko / umbala: White ukuya kwi-crystal ye-crystal etyheli
● Uxinzelelo lwe-vapor: 7.45e-05mmhg nge-25 ° C
● Inqaku lokunyibilika: I-220 ukuya kwengama-30 ° C
● Isalathiso seNgxelo ye-Recofe: 1.603
● Inqaku lokubila: 328.8 ° C nge-760 mmhg
● I-PKA: 1.81 ± 0.10 (iqikelele)
● Inqaku leFlash: 152.7 ° C
● psa:I-63.32000
● Ukuxinana: 1.392 g / cm3
● I-LOGP: 2.12440

● Indawo yokugcina i-temp.
● Ukuzithoba ngenxa ye-cozisorb kwi-0.1MOL / L Nah (phantse i-phantse).
● I-XlogP3: -1.1
● I-Hydrogen Bop Count Count: 2
● Ubalo lwe-Hydrogen Bopptor: 3
● I-Count Count Count: 2
● Ubunzima obuthe ngqo: 185.0243562
● Ukubalwa kweatom enzima: 12
● Ukuntsonkotha: 166

Ulwazi olukhuselekileyo

● I-pictogram (s):Xn
● Iikhowudi zengozi: xn
● Iingxelo: 22-36 / 37/38
● Iingxelo zoKhuseleko: 26-36

Iluncedo

I-Canonical iyancuma:I-C1 = cc (= cc = c1c (c (= o) o) o) N) Cl
IISEBE:Yinto ebalulekileyo eluhlaza kwaye isetyenziswe kwi-ornthesic synthesis, amayeza, i-agrochemicals kunye ne-dystuff.

Intshayelelo Eneenkcukacha

I-2-Amino-2- (4-Chloropheny) I-Acetic Acid ikwaziwa ngegama lekhemikhali, i-4-chloro-amino -zenzenzenzenzenzenzenzenzenzenzenezetic acid. Yinto yomgubo we-crystalline emhlophe ngefomula yemolekyuli ye-C8H8CLno2 kunye nobunzima bemolekyuli ye-185.61 g / mol.
Nazi ezinye iinkcukacha malunga ne-2-Amino-2- (4-chlorophenyl) i-acetic acid:
Synthesis:Le computha inokufakwa ngeendlela ezahlukeneyo, kubandakanya impendulo ye-4-chloroacetophenone nge-gelycine phambi kommeli wokunciphisa i-sodhydride, okanye ngempendulo ye-chlohyl bromide nge-sodium nge-sodium glycinate.
Iipropathi zomzimba kunye neekhemikhali:
Inqaku le-1.meltha: Indawo yokunyibilika ye-2-Amino-2- (4-chloropheny) I-Acetic Acid iqhele ukuba ijikeleze i-135-140 ° C.
2.Ukuhlala: Inyibilikiswa ngamanzi, kodwa inyibilike kakuhle kwiinyibiliki ezifana ne-ethanol kunye ne-methanol.
3.phse: Kwisisombululo esinamandla, le phunga ibuthathaka ngeapidic ene-acid nge-5-6.
Ipropathi yebhayoloji:
Imisebenzi ye-1.pharmarmacociologicage: Nangona kukho ulwazi olulinganiselweyo olufumaneka kwimisebenzi ye-2-amino-2- (4-Chloropheny) i-acetic acid, ezinye izifundo zibonisa ukuba zinokubakho iipropathi ezivunyiweyo kunye ne-analgesic.
2.mettabolism: Ikhondo le-metabolic lale mitha ebantwini alibhalwe kakuhle. Nangona kunjalo, kulindeleke ukuba kubekho ukohlukana okuqinisekileyo kunye nokupheliswa emzimbeni.
Ukuqwalaselwa ngokukhuselekileyo:
1.Nge-2-Amino-2- (4-Chloropheny) I-Acetic Acid ithathelwa ingqalelo ukuba inobuqili, kucetyiswa ukuba ikwazi ukusingatha ngokulumkileyo kwaye isebenze kunye nokusebenza kunye nokusebenza kunye nokusebenza kunye nokusebenza kunye nokusebenza kwe-comple.
2.Ukuba kubalulekile ukunxiba izixhobo zokhuselo, ezinjengeegloves kunye neegogo, kunye nokuqinisekisa ukonwaba ngokufanelekileyo xa usebenza nale nto.
3.Ukubhengeza amaphepha edatha yoKhuseleko (i-SDS) kwaye unxibelelanisise izikhokelo ezifanelekileyo zokhuseleko kunye nemigaqo xa uphatha kwaye usebenzisa le comple.
Khumbula, ulwazi olunikezwe apha luqwalaselo ngokubanzi kwaye akufuneki luthathelwe ingqalelo njengokuphumelela okanye ukuphelisa. Kwizicelo okanye iinjongo ezithile, kusoloko kucetyiswa ukuba banxibelelane noncwadi olukhethekileyo okanye imithombo ethembekileyo yolwazi oluneenkcukacha.

Isicelo

2-Amino-2- (4-Chlorophenyl) I-Acetic Acid, ekwabizwa ngokuba yi-4-Chloro-Aphasi-Aminobenzenzenzenezetic acid, inezicelo ezinokubakho kwimimandla eyahlukeneyo. Nazi ezinye izicelo ezinokwenzeka:
Ishishini lamachiza:
1.I-Synthesis yeziyobisi: inokusetyenziswa njengebhlokhi yesakhiwo okanye iphakathi kwi-synthesis yezinto ezifana ne-analgesics, i-anti-insulmarics, okanye intsholongwane.
2.Uphuhliso lwe-Prodrug: 2-Amino-2- (4-Chloropheny) I-Acetic Acid inokusetyenziselwa ukukhulisa ii-prodrugs, eziziyo zokungasebenzi okanye ezingenazichiza eziguqulweyo zikwimo esebenzayo emzimbeni. Oku kunokunceda ukuphucula ukusebenza kweziyobisi, i-bioaaaiffey, okanye ukunciphisa iziphumo ebezingalindelekanga.
UPhando lweeKhemikhali:
1.I-Synthesic Synthesis: I-compound inokusetyenziswa kwilabhoratri yezinto eziphilayo ze-organic, ngakumbi kwi-synthesis yezinto ezikhoyo zezinto ezikhoyo.
2.I-Ligady Synthesis: Ingasetyenziselwa ukulungiswa kwee-ligands zokulungelelanisa chemistry okanye i-catalysts yezinto ezahlukeneyo zekhemikhali.
Ishishini lezoLimo:
1.UPhuhliso lweZihlalo zeScinci
Uphando nophuhliso:
1.Uphando lweekhemikhali: Eli candelo linokusetyenziswa njengomgangatho okanye ireferensi edityanisiweyo yeenjongo zohlalutyo kunye nophuhliso lweendlela ezikwiilebhu zophando.
2.Uphando lwebhayoloji: inokusetyenziswa kwizifundo eziphandayo Indima kunye nezixhobo zabo kwi-biectological okanye ye-biochemical pames.
Nceda uqaphele ukuba izicelo ezithile kunye nokusetyenziswa kwe-2-Amino-2- (4-Chloropheny) I-acetic acid inokuxhomekeka kuphando nophuhliso. Hlala ujonga uncwadi lwesayensi, iimfuno zolawulo, kunye neengcali ezifanelekileyo ngaphambi kokusebenzisa okanye ukuthathela ingqalelo isicelo sayo kwicandelo elithile.