Iimveliso
N-Methyl-2-pyrrolidone
Pyrrolidone Chemical Properties
| Indawo yokunyibilika | -24 °C (isibane.) |
| Indawo yokubilisa | 202 °C (lit.) 81-82 °C/10 mmHg (ilayiti.) |
| ukuxinana | 1.028 g/mL ku-25 °C (lit.) |
| ukuxinana komphunga | 3.4 (vs umoya) |
| uxinzelelo lomphunga | 0.29 mm Hg ( 20 °C) |
| isalathiso se-refractive | n20/D 1.479 |
| Fp | 187 °F |
| ixesha lokugcina. | Gcina ku +5°C ukuya +30°C. |
| ukunyibilika | ethanol: miscible0.1ML/mL, icacile, ayinambala (10%, v/v) |
| ifomu | Ulwelo |
| pka | -0.41±0.20(Kuxelwe kwangaphambili) |
| umbala | ≤20(APHA) |
| PH | 8.5-10.0 (100g/l, H2O, 20℃) |
| Ivumba | Ivumba le-amine elincinci |
| PH Uluhlu | 7.7 - 8.0 |
| umda wokuqhushumba | 1.3-9.5%(V) |
| Ukunyibilika kwamanzi | >=10 g/100 mL ku-20 ºC |
| Inovakalelo | Hygroscopic |
| λmax | 283nm(MeOH)(lit.) |
| Merck | 14,6117 |
| I-BRN | 106420 |
| Uzinzo: | Izinzile, kodwa ibola yakuba sichanabeke ekukhanyeni.Ukutsha.Ukungahambelani ne-oxidizing agents ezinamandla, i-acids eqinile, i-agent yokunciphisa, iziseko. |
| InChIKey | I-SECXISVLQFMRJM-UHFFFAOYSA-N |
| LogP | -0.46 kwi-25℃ |
| CAS Database Reference | 872-50-4(CAS Database Reference) |
| NIST Chemistry Reference | I-2-Pyrrolidinone, i-1-methyl-(872-50-4) |
| EPA Substance Registry System | I-N-Methyl-2-pyrrolidone (872-50-4) |
Ulwazi ngoKhuseleko
| Iikhowudi zeNgozi | T,Xi |
| Iingxelo zoMngcipheko | 45-65-36/38-36/37/38-61-10-46 |
| Iingxelo zoKhuseleko | 41-45-53-62-26 |
| WGK eJamani | 1 |
| RTECS | UY5790000 |
| F | 3-8-10 |
| Autoignition Temperature | 518 °F |
| I-TSCA | Y |
| Ikhowudi ye-HS | 2933199090 |
| Idatha yezinto ezinobungozi | 872-50-4(Idatha yezinto ezinobungozi) |
| Ubutyhefu | LD50 ngomlomo kuMvundla: 3598 mg/kg LD50 dermal Rabbit 8000 mg/kg |
Ukusetyenziswa kwePyrrolidone kunye ne-Synthesis
| Iipropati zeMichiza | I-N-Methyl-2-pyrrolidone lulwelo olungenambala ukuya ekukhanyeni olutyheli olucacileyo olunevumba elincinane le-ammonia.I-N-Methyl-2-pyrrolidone ixutywe ngokupheleleyo ngamanzi.Inyibilika kakhulu kwii-alcohols ezisezantsi, iiketones ezisezantsi, i-ether, i-ethyl acetate, i-chloroform, kunye ne-benzene kwaye inyibilika ngokuphakathi kwi-aliphatic hydrocarbons.I-N-Methyl-2-pyrrolidone inamandla e-hygroscopic, i-chemicals stable, ayigxumeki kwi-carbon steel kunye ne-aluminiyam, kwaye i-corrosive kancinane kubhedu.Inoncamathela ephantsi, ikhemikhali eyomeleleyo kunye nokuzinza kwe-thermal, i-polarity ephezulu, kunye nokuguquguquka okuphantsi.Le mveliso inetyhefu encinci, kwaye umda wayo ovunyelweyo woxinaniso emoyeni ngu-100ppm.
|
| Usebenzisa |
|
| ubuthi | Oral (mus)LD50:5130 mg/kg;Oral (rat)LD50:3914 mg/kg;Dermal (rbt)LD50:8000 mg/kg. |
| Ukukhupha inkunkuma | Qhagamshelana nemithetho yelizwe, yendawo okanye yelizwe ngokufanelekileyo.Ukulahlwa kufuneka kwenziwe ngokwemigaqo esemthethweni.Amanzi, ukuba kuyimfuneko kunye neearhente zokucoca. |
| yokugcina | I-N-Methyl-2-pyrrolidone i-hygroscopic (ithatha umswakama) kodwa izinzile phantsi kweemeko eziqhelekileyo.Iya kusabela ngobundlobongela kunye ne-oxidizers eyomeleleyo efana ne-hydrogen peroxide, i-nitric acid, i-sulfuric acid, njl njl. Iimveliso eziphambili zokubola zivelisa i-carbon monoxide kunye ne-nitrogen oxide imisi.Ukutyhileka okugqithisileyo okanye ukuchitheka kufuneka kuphetshwe njengombandela wokuziqhelanisa kakuhle.Inkampani yeLyondell Chemical incoma ukunxiba iiglavu ze-butyl xa usebenzisa i-N-Methyl-2-pyrrolidone.I-N-Methyl-2-pyrrolidone kufuneka igcinwe kwindawo ecocekileyo, ene-phenolic-lined mild steel or alloy drums.I-Teflon®1 kunye ne-Kalrez®1 zibonakaliswe njengezixhobo ezifanelekileyo ze-gasket.Nceda ujonge i-MSDS ngaphambi kokuba uyiphathe. |
| Inkcazo | I-N-Methyl-2-pyrrolidone yi-solvent ye-aprotic eneendlela ezininzi zokusetyenziswa: i-petrochemical processing, i-surface coating, idayi kunye ne-pigments, i-industrial kunye ne-community compounds yokucoca, kunye nokuveliswa kwezolimo kunye neyeza.Ikakhulu iyacaphukisa, kodwa ibangele iimeko ezininzi zoqhagamshelwano lwedermatitis kwinkampani encinci ye-electrotechnical. |
| Iipropati zeMichiza | I-N-Methyl-2-pyrrolidone lulwelo olungenambala okanye olukhanyayo olutyheli olunevumba le-amine.Iyakwazi ukujongana nenani leekhemikhali ezisabelayo nangona yamkelwe njenge-solvent ezinzileyo.Inganyangeki kwi-hydrolysis phantsi kweemeko ezingathathi hlangothi, kodwa i-asidi eqinile okanye unyango olusisiseko lubangela ukuvulwa kwendandatho kwi-4-methyl aminobutyric acid.I-N-Methyl-2-pyrrolidone ingancitshiswa ibe yi-1-methyl pyrrolidine kunye ne-borohydride.Unyango olune-chlorinating agents lukhokelela ekwakhekeni kwe-amide, indawo ephakathi enokuthi ithathelwe indawo ngakumbi, ngelixa unyango nge-amyl nitrate luvelisa i-nitrate.I-Olefins inokongezwa kwindawo ye-3 ngonyango kuqala nge-oxalic esters, ngoko kunye ne-aldehyes efanelekileyo (uHort noAnderson 1982). |
| Usebenzisa | I-N-Methyl-2-pyrrolidone yi-solvent ye-polar esetyenziswa kwi-organic chemistry kunye ne-polymer chemistry.Ukusetyenziswa komlinganiselo omkhulu kubandakanya ukubuyiswa kunye nokuhlanjululwa kwe-acetylenes, i-olefins, kunye ne-diolefins, ukuhlanjululwa kwegesi, kunye ne-aromatics extraction kwi-feedstocks.I-NMP okwangoku yamkelwe ukuba isetyenziswe kuphela kunyango lwezilwanyana.Ukumiselwa kokulahlwayo kunye nemetabolism ye-NMP kwimpuku kuya kuba negalelo ekuqondeni ubutyhefu bale khemikhali yangaphandle apho umntu anokuthi abe sesichengeni kuwo ngokwezixa-mali ezikhulayo. |
| Usebenzisa | I-solvent ye-resins ephezulu yobushushu;ukusetyenzwa kwepetrochemical, kwishishini le-microelectronics fabrication, iidayi kunye neepigments, iikhompawundi zokucoca kumashishini kunye nekhaya;ukwakhiwa kwezolimo kunye namayeza |
| Usebenzisa | I-N-Methyl-2-pyrrolidone, iluncedo kwi-spectrophotometry, i-chromatography kunye nokufumanisa i-ICP-MS. |
| Ingcaciso | I-ChEBI: Ilungu leklasi ye-pyrrolidine-2-enye i-pyrrolidin-2-enye apho i-hydrogen efakwe kwi-nitrogen ithathelwa indawo liqela le-methyl. |
| Iindlela zeMveliso | I-N-Methyl-2-pyrrolidone yenziwa ngokusabela kwe-buytrolactone nge-methylamine (Hawley 1977).Ezinye iinkqubo ziquka ukulungiswa nge-hydrogenation yezisombululo ze-maleic okanye i-succinic acids kunye ne-methylamine (uHort noAnderson 1982).Abavelisi bale khemikhali baquka iLachat Chemical, Inc, Mequon, Wisconsin kunye neGAF Corporation, iCovert City, eCalifornia. |
| IiReferensi zeNdibaniselwano | Iileta zeTetrahedron, i-24, iphe.1323, 1983DOI: 10.1016/S0040-4039(00)81646-9 |
| Inkcazo ngokubanzi | I-N-Methyl-2-Pyrrolidone (NMP) yinto enamandla, i-aprotic solvent ene-solvency ephezulu, kunye nokuguquguquka okuphantsi.Lo manzi angenambala, abilayo aphezulu, aphezulu aphezulu kunye nolwelo oluphantsi lomphunga luthwala ivumba elithambileyo elifana ne-amine.I-NMP inemichiza ephezulu kunye nokuzinza kwe-thermal kwaye ixutywe ngokupheleleyo ngamanzi kuwo onke amaqondo obushushu.I-NMP inokusebenza njenge-co-solvent ngamanzi, i-alcohol, i-glycol ethers, ii-ketones, kunye ne-aromatics/chlorinated hydrocarbons.I-NMP inokuphinda isetyenziswe ngokuxutywa kunye ne-biodegradable ngokulula.I-NMP ayifumanekanga kuluhlu lweziNgcolisi zoMoya ezinobungozi (HAPs) zoLungiso lwe-1990 loMthetho woMoya ococekileyo. |
| Iintshukumo zoMoya naManzi | Inyibilika emanzini. |
| Iprofayile yeReactivity | Le amine isiseko sekhemikhali esithambileyo kakhulu.I-N-Methyl-2-pyrrolidone ithanda ukwenza ii-asidi zibe buthathaka ukwenza iityuwa kunye namanzi.Ubungakanani bobushushu obuguquguqukayo kwi-mole ye-amine kwi-neutralization ubukhulu becala buzimeleyo kumandla e-amine njengesiseko.I-amines inokungahambelani ne-isocyanates, i-halogenated organics, i-peroxides, i-phenols (i-acidic), i-epoxides, i-anhydrides, kunye ne-asidi halides.I-hydrogen evuthayo yegesi evuthayo yenziwa ngama-amine ngokudibanisa kunye nee-agent zokunciphisa ezinamandla, ezifana ne-hydrides. |
| Ingozi | Ulusu olubi kunye nokucaphukisa kwamehlo.Umlinganiselo oqhumayo-i-2.2-12.2%. |
| Ingozi yeMpilo | Ukuphefumla umphunga oshushu kunokucaphukisa impumlo nomqala.Ukusela kubangela ukucaphuka komlomo kunye nesisu.Ukudibana namehlo kubangela ukucaphuka.Uqhagamshelwano oluphindaphindiweyo kunye nolude lwesikhumba luvelisa ukucaphuka okuncinci, okwethutyana. |
| Ingozi yoMlilo | Iingozi eziKhethekileyo zeeMveliso ezitshiswayo: Iioksidi ezinetyhefu zenitrogen zisenokwenziwa emlilweni. |
| Ukutsha kunye nokuSebenza | Ayinakutsha |
| Ukusetyenziswa kwemizi-mveliso | I-1) I-N-Methyl-2-pyrrolidone isetyenziswe njenge-solvent ye-dipole ye-aprotic jikelele, i-stable and unreactive; 2) ukutsalwa kwee-hydrocarbons ezinevumba elimnandi kwii-oyile zokuthambisa; 3) ukukhutshwa kwe-carbon dioxide kwii-generator ze-ammonia; 4) njenge-solvent ye-polymerization reactions kunye ne-polymers; 5) njengepeyinti yepeyinti; 6) ukwenzela ukwakhiwa kwezinambuzane (USEPA 1985). Olunye usetyenziso olungekho kwimizi-mveliso ye-N-Methyl-2-pyrrolidone lusekelwe kwiipropati zayo njenge-solvent ehlukanisayo efanelekileyo kwizifundo ze-electrochemical kunye ne-physical chemical studies (Langan noSalman 1987).Usetyenziso lwamachiza lwenza ukusetyenziswa kweempawu ze-N-Methyl-2-pyrrolidone njengesixhasi sokungena sogqithiso olukhawulezayo lwezinto ngolusu (Kydoniieus 1987; Barry and Bennett 1987; Akhter and Barry 1987).I-N-Methyl-2-pyrrolidone ivunyiwe njenge-solvent yesicelo se-slimicide kwizinto zokupakisha ukutya (USDA 1986). |
| Qhagamshelana nezinto ezidityanisiweyo | I-N-Methyl-2-pyrrolidone yi-solvent ye-aprotic eneendlela ezininzi zokusetyenziswa: i-petrochemical processing, i-surface coating, idayi kunye ne-pigments, i-industrial kunye ne-community compounds yokucoca, kunye nokuveliswa kwezolimo kunye neyeza.Ikakhulu iyinto ecaphukisayo, kodwa inokubangela ukudibana okukhulu kwe-dermatitis ngenxa yoqhagamshelwano olude. |
| Inkangeleko yoKhuseleko | Ityhefu ngokufakwa emithanjeni.Ityhefu ephakathi ngokuginya kunye neendlela ze-intraperitoneal.Ityhefu kancinci ngokudibana kwesikhumba.I-teratogen yovavanyo.Iziphumo zovavanyo lokuzala.Idatha yokuguqulwa kwengxelo.Inokutsha xa isesichengeni sobushushu, ilangatye elivulekileyo, okanye ii-oxidizers ezinamandla.Ukulwa nomlilo, sebenzisa i-foam, i-CO2, ikhemikhali eyomileyo.Xa ishushu ukuze ibole ikhupha imisi eyityhefu yeNOx. |
| I-Carcinogenicity | Iigundane zibonakaliswe kwi-N-Methyl-2-pyrrolidone vapor kwi-0, 0.04, okanye i-0.4 mg / L ye-6 h / imini, iintsuku ze-5 / iveki ye-2 iminyaka.Akukho ziphumo zokunciphisa ubomi ezinobuthi ezinobuthi okanye ze-carcinogenic zabonwa kwiigundane ezivezwe iminyaka eyi-2 ukuya kwi-0.04 okanye i-0.4mg / L ye-N-Methyl-2-pyrrolidone.Ngomzila we-dermal, iqela le-32 yeegundane lifumene i-dose yokuqalisa ye-25mg ye-N-Methyl-2-pyrrolidone elandelwa kwiiveki ze-2 kamva ngokusetyenziswa kwe-tumor promoter phorbol myristate acetate, kathathu ngeveki, ngaphezu kweeveki ze-25.I-Dimethylcarbamoyl chloride kunye ne-dimethylbenzanthracene zisebenze njengolawulo oluhle.Nangona iqela le-N-Methyl-2-pyrrolidone lalinamathumba esikhumba amathathu, le mpendulo ayizange ithathelwe ingqalelo njengento ebalulekileyo xa ithelekiswa neyolawulo oluhle. |
| Indlela ye-metabolic | Iimpuku zilawulwa ngonomathotholo obhalwe i-N-methyl-2- pyrrolidinone (NMP), kwaye eyona ndlela iphambili yokukhutshelwa ziimpuku ngomchamo.I-metabolite enkulu, emele i-70-75% yedosi elawulwayo, yi-4-(methylamino) butenoic acid.Le mveliso engaguqukiyo inokuthi yenziwe ekupheliseni amanzi, kwaye iqela le-hydroxyl linokuba khona kwi-metabolite ngaphambi kwe-acid hydrolysis. |
| Imetabolism | Iigundane ze-Male Sprague-Dawley zanikwa i-injection eyodwa ye-intraperitoneal (45 mg / kg) ye-radiolabeled 1 -methyl-2-pyrrolidone.Amanqanaba e-Plasma e-radioactivity kunye ne-compound abekwe esweni iiyure ezintandathu kwaye iziphumo zacebisa isigaba sokusabalalisa ngokukhawuleza esalandelwa sisigaba esicothayo sokuphelisa.Isixa esikhulu seleyibhile sakhutshwa kumchamo kwiiyure ze-12 kwaye sibalwa malunga ne-75% yedosi ebhaliweyo.Iiyure ezingamashumi amabini anesine emva kwedosi, ukukhutshelwa kokuphuma (umchamo) kwakumalunga nama-80% ethamo.Zombini iintlobo zeringi kunye ne-methyl-ezibhalwe zisetyenzisiwe, kunye nazo zombini [14C]- kunye ne- [3H]-ebhalwe l-methyl-2-pyrrolidone.Imilinganiselo yokuqala ebhaliweyo yagcinwa ngexesha leeyure zokuqala ze-6 emva kwedosi.Emva kweeyure ezi-6, isibindi kunye namathumbu afunyaniswa equlethe i-accumulations ephezulu ye-radioactivity, malunga ne-2-4% yedosi.I-radioactivity encinci yaphawulwa kwi-bile okanye umoya ophefumlelweyo.Ukusebenza okuphezulu kwechromatography yolwelo yomchamo kubonise ubukho bemetabolites enye enkulu kunye neencinci ezimbini.I-metabolite enkulu (i-70-75% yedosi ye-radioactive elawulwayo) yahlaziywa yi-liquid chromatography-mass spectrometry kunye ne-gas chromatography-mass spectrometry kwaye yacetywa ukuba ibe yi-3- okanye i-5-hydroxy-l-methyl-2-pyrrolidone (Wells 1987). |
| Iindlela zokucoca | Yomisa ipyrrolidone ngokususa amanzi njenge *benzene azeotrope.I-fractionally distil kwi-10 torr ngokusebenzisa ikholomu ye-100-cm epakishwe ngeeheliksi zeglasi.[Adelman J Org Chem 29 1837 1964, McElvain & Vozza J Am Chem Soc 71 896 1949.] I-hydrochloride ine-m 86-88o (ukusuka kwi-EtOH okanye i-Me2CO/EtOH) [Reppe et al.UJustus Liebigs Ann Chem 596 1 1955].[Beilstein 21 II 213, 21 III/IV 3145, 21/6 V 321.] |
Bhala umyalezo wakho apha kwaye uwuthumele kuthi
