Iimveliso
N, n'-diapropylCarpylbodiimial; I-CASS.: 693-13-0-0-0
Izithethantonye: I-1,3-diisopropylbodiimide
Ipropathi yamachiza e-N, n'-diapropylCarpylbodiimiimide
● Ukubonakala / umbala
● Uxinzelelo lwe-vapor: 34.9HPA ngo-55.46 ℃
● Inqaku lokunyibilika: 210-212 ° C (Disec)
● Isalathiso seNgxelo yeNgxelo: I-N20 / D 1.433 (I-LAL.)
● Inqaku lokubilisa: i-146.5 ° C nge-760 mmhg
● Inqaku leFlash: 33.9 ° C
● psa:I-24.72000
● Ukuxinana: 0.83 G / CM3
● I-Logp: 1.97710
● Indawo yokugcina i-temp. -
● Ubuthathaka
● Solubiss.: I-Cozisoble kwiChloroform, Methylene Chloride, Acetonitrile, Dioxane
● I-XlogP3: 2.6
● I-Hydrogen Bop Count Count: 0
● Ubalo lwe-Hydrogen Bopptor: 2
● I-Count Count Count: 2
● Ubunzima obuthe ngqo: 126.115698455
● Ukubalwa kweatom enzima: 9
● Ukuntsonkotha: 101
Ulwazi olukhuselekileyo
● I-pictogram (s): T +,
T,
F
● Iikhowudi zengozi: T +, T, F, XN
● Iingxelo: 10-26-366 / 37/8-412222237 / 38
● Iingxelo zoKhuseleko: 26-36 / 37/9-45-38-38-28a-16-26-26
Iluncedo
Iiklasi zekhemikhali:I-Nitrogen Compows -> Ezinye ii-computer zeNitrogen
I-Canonical iyancuma:I-CC (c) n = c = nc (c) c
Izilingo zekliniki zamva nje ze-EU:Iziphumo zexesha elide ze-Aldara? I-5% cream kwaye
I-echaza i-ebricondoPropylbodiimide (dic) lulwelo olucacileyo olunokupheliswa ngokulula ngumthamo. Ikhula kancinci kancinci ngomswakama emoyeni, ke ukugcina indawo yexesha elide ibhotile kufuneka ihambe ngomoya owomileyo okanye irhasi ye-inter kwaye itywinwe ngokuqinileyo. Isetyenziswe kwi-camistry yepikisi njengendawo yokudibana kwakhona. Ibiyityhefu kakhulu kwaye yabangela ukunxibelelana ne-dermatitis kumsebenzi welebhu.
IISEBE:Le mveliso isetyenziswa ikakhulu kwiAmikacacin, i-Glutathione Deghts, kunye neSyntdars, kunye neSynthedas ye-Acid Anhydride, i-Aldehyde, iKetonate; Xa isetyenziswa njengeHleyinti yeHesment, iphendula kwi-dicylohexylire yokuphendula yexesha elifutshane phantsi kobushushu obuqhelekileyo. Le mveliso inokusetyenziswa kwi-synthesi ye-peptide kunye ne-nucleic acid. Kulula ukusebenzisa le mveliso ukusabela nge-computer ye-carboxy yasimahla kunye ne-Amino-Group kwiPeplate. Le mveliso isetyenziswa ngokubanzi kwezonyango, impilo, yenza iimveliso zebhayoloji, kunye namanye amasimi owenziwayo. N, I-N'-DiisopropylboDIimide isetyenziswa njenge-regent kwi-slinthec chemistry. Isebenza njengekhemikhali ephakathi kwaye njenge-stabilizer ye-sarin (isixhobo samachiza). Ikwasetyenziswa kwi-synthesis ye-peptide kunye ne-nucleic acid. Ngaphaya koko, isetyenziswa njenge-antineplastic kwaye ibandakanyeke kunyango lwe-melanoma etyhafileyo kunye ne-sarcos. Ukongeza koku, isetyenziswa kwi-synthesis ye-acid anhydride, i-Aldehyde, iKendonate kunye ne -bekopo.
Intshayelelo Eneenkcukacha
N, N'-NisoPropylboDIimide, oqhele ukuncitshiswa njenge-DIC, yindawo yemichiza ngefomula c7h14n2. Lulwelo olungenamibala olungenamibala lunyibilikisi kwiinyibiliki ezifanayo zezinto eziqhelekileyo ezinjengoothuna. I-Dic isetyenziswe ngokubanzi njenge-synthesic synthesic regent kwaye idlala indima ebalulekileyo kwimisebenzi eyahlukeneyo yemichiza.
I-Dic isetyenziswa njenge-arhente yokudibanisa kwi-Synthesis ye-Peptide, eyinkqubo yokujoyina i-Amino Acids kunye ukuba yenze izikhonkwane okanye iiproteni. Isebenza njengendawo yokuqalisa i-positing, iququzelele ukudibanisa ii-Amino Acids ngokwenza amaqela e-carboxyl, ngokuqhelekileyo ngokuqulunqwa kweyona nto iphambili ekuboneni. Esi siPhakathi siphi esiPhakathi kunye namaqela ase-Amino ngaphambi kokuba baphinde babe nohlengahlengiso kunye nokupheliswa kokuvelisa iqhina lePeptide.
I-DIC ikwaqeshwe kwenye indlela yokuphendula engaphaya kwe-peptide, njengoku-Esterical, imixholo, kunye nerenthene synthesis. Isebenza njenge-demer yokuphelelwa ngamathambo kwezi zinto, ukuqhubela phambili ukususwa kweemolekyuli zamanzi, ngokwenza malunga nokuphendula okufuneka ngaphambili.
Ngenxa yoku-odoli kwaye ivumba elinamandla, i-dic kufuneka iphathwe ngononophelo. Ihlala isetyenziswa kwi-hood evuthiweyo ye-hood kunye neegloves ezikhuselayo kufuneka zinxitywe ukuthintela unxibelelwano lwesikhumba. Ukongeza, njengayo nayiphi na imichiza, kubalulekile ukuba ulandele iinkqubo ezifanelekileyo zokhuseleko kwaye unxibelelane nephepha lokhuseleko lokhuseleko lwezinto ezibonakalayo (MSD) ngolwazi oluneenkcukacha.
Isishwankathelo, n, i-N'-Dialoptropylbodiimide yindlela yokuqhubela phambili esetyenziswayo kwiSynthesi ye-orgation, kubandakanya i-synthesis, kuquka i-Synthesis, i-Esterides, kunye no-urenthene synthene. Indima yayo njenge-arhente ye-coupling kunye nehlelo lokuphelelwa ngamathambo iyenza isixhobo esibalulekileyo kwicandelo le-chemistry.
Isicelo
N, I-N'-DiisopropylboDIimide (dic) ineemali ezininzi ezibalulekileyo kwi-synthesis yendalo kunye nophando ngamayeza. Nazi ukusetyenziswa okukhethekileyo kwe-dic:
I-Peptide Synthesis:I-DIC iqhele ukusetyenziswa njenge-arhente yokudibana kwi-Spride yeSigaba se-Peptide ye-Peptide Fortide Bonds phakathi kwe-Amino Acids. Isebenza amaqela e-carboxyl yee-acids ezikhuselweyo ze-Amino, zibavumela ukuba baphendule ngamaqela ase-Amino, okukhokelela ekumiselweni kwebhondi yepeptider.
Indawo yokuPhakanyiswa kunye nokuPhakanyiswa okuBanzi:I-Dic iqeshiwe njengearhente yokuphelelwa ngamathambo ukukhuthaza i-prountes yebhokisi ye-carboxylic kunye nemilambo okanye ilokishi eluphangelaneyo kunye nokusabela ngokulandelelana. Iququzelela ukumiswa kwezinto kwaye i-esters ngokususa amanzi kumxube wokuphendula.
Irethane Synthesis:I-Dic inokusetyenziswa njengearhente yokudibanisa kwi-synthesis ye-Urethane yeCompows. Yenza ukuba iphendule phakathi kokungahlukaniswa phakathi kweendawo ezine-cares kunye notywala ukuze zenze urethanes.
I-Carbodiimide-I-Coupiling Reuping:I-DIC ihlala isetyenziswa njengendawo yokudibana kwakhona kwimisebenzi eyahlukeneyo yezinto eziphilayo, njengeSomandla ye-Amisside, ilitha, kunye nezinye izinto zebhayiloji. Ikhuthaza ukudityaniswa kwee-carboxylic acids, i-acid chloride, okanye i-azide ye-azines enama-Azines, i-hydroxylamines, kunye nezinye iinyukliya.
Inguqu ye-OXIDAM:I-Dic isetyenziselwa ukuphendula kwe-oxidage, njengokucoceka kwe-oxidive ye-olefins kunye ne-oxidation ye-sulffides ukuya kwizifo ezikhulu okanye i-sulfone.
Kubalulekile ukuba uqaphele ukuba i-DIC ingumoya- kunye nokufuma, ibuthathaka, ke kufuneka ihlawulwe kwindawo enomoya okanye phantsi kwe-InErt. Ukongeza, amanyathelo okhuseleko, anjengeigloves kunye neeglasi, kufuneka athathwe xa esebenza nge-dayic ngenxa yendalo eyingozi.
